Ramon Klein Geltink
Department of Pathology and Laboratory Medicine
Faculty of Medicine
Dr. Ramon Klein Geltink completed his PhD in Molecular Biology at St. Jude Children’s Research Hospital / Erasmus University and his postdoctoral training in immunometabolism at the Max Planck Institute for Immunobiology and Epigenetics.
Research in the Klein Geltink lab focusses on metabolic regulation of immune cell function, with a particular interest in mechanisms of nutrient sensing in immune cells. We use molecular biology, immunological techniques, stable isotope tracing, and metabolomics to further our understanding on what is needed for a protective immune response, and how metabolic dysfunction leads to immune-related pathologies. The overall goal of this research program is to develop therapeutic strategies for immunomodulation to enhance immune cell function in cellular therapies of cancer, and to dampen the immune response in autoimmune diseases.
Research interests: Immunometabolism, Cancer Immunotherapy, Stable Isotope Tracing, Metabolomics, Nutrient Sensing, Signal Transduction, Post-Translational Modifications.